ABSTRACT
A 43-year-old man presented with cardiac arrest 2 days after the second coronavirus disease 2019 (COVID-19) vaccination with an mRNA vaccine. Electrocardiograms showed ventricular fibrillation and type 1 Brugada pattern ST segment elevation. The patient reported having no symptoms, including febrile sensation. There were no known underlying cardiac diseases to explain such electrocardiographic abnormalities. ST segment elevation completely disappeared in two weeks. Although there were no genetic mutations or personal or family history typical of Brugada syndrome, flecainide administration induced type 1 Brugada pattern ST segment elevation. This case suggests that COVID-19 vaccination may induce cardiac ion channel dysfunction and cause life threatening ventricular arrhythmias in specific patients with Brugada syndrome.
Subject(s)
Brugada Syndrome , COVID-19 , Male , Humans , Adult , Brugada Syndrome/diagnosis , Brugada Syndrome/etiology , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/etiology , COVID-19 Vaccines/adverse effects , Electrocardiography/adverse effects , Vaccination/adverse effectsSubject(s)
Coronavirus Infections/epidemiology , Heart Arrest/therapy , Heart Valve Diseases/diagnostic imaging , Mitral Valve/diagnostic imaging , Occupational Stress/physiopathology , Physicians , Pneumonia, Viral/epidemiology , Ventricular Fibrillation/therapy , Adult , Betacoronavirus , COVID-19 , Defibrillators, Implantable , Echocardiography , Female , Heart Arrest/diagnosis , Heart Arrest/etiology , Heart Valve Diseases/complications , Heart Valve Diseases/physiopathology , Humans , Magnetic Resonance Imaging , Occupational Stress/complications , Pandemics , SARS-CoV-2 , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/etiology , Ventricular Fibrillation/physiopathologyABSTRACT
Cardiac arrhythmia is a known manifestation of novel coronavirus 2019 (COVID-19) infection. Herein, we describe the clinical course of an otherwise healthy patient who experienced persistent ventricular tachycardia and fibrillation which is believed to be directly related to inflammation, as opposed to acute myocardial injury or medications that can prolong the QT interval.